The coordinating centre will provide background information, check that the potential investigator understands the protocol and has previous trial experience, check that the site has sufficient staffing and equipment level and that a reasonable number of eligible patients can be expected during the duration of the trial.

The principal investigator should discuss the feasibility of the trial with heads of other departments whose co-operation may be required in carrying out the trial treatment and follow-up. Without their agreement the trial cannot be successful.